摘要
Genomics,an interdisciplinary field of biology on the structure,function,and evolution of genomes,has revolutionized many subdisciplines of life sciences,including my field of evolutionary biology,by supplying huge data,bringing high-throughput technologies,and offering a new approach to biology.In this review,I describe what I have learned from genomics and highlight the fundamental knowledge and mechanistic insights gained.I focus on three broad topics that are central to evolutionary biology and beyond—variation,interaction,and selection—and use primarily my own research and study subjects as examples.In the next decade or two,I expect that the most important contributions of genomics to evolutionary biology will be to provide genome sequences of nearly all known species on Earth,facilitate high-throughput phenotyping of natural variants and systematically constructed mutants for mapping genotype–phenotype–fitness landscapes,and assist the determination of causality in evolutionary processes using experimental evolution.
基金
I am grateful to former and current associates for their contributions to my laboratory’s work reviewed here and to the U.S.National Institutes of Health for funding(Grant No.R35GM139484).
