硝呋太尔联合环丙沙星栓对细菌性阴道炎患者炎症反应与氧化应激的影响

Effect of Nifurtel Combined with Ciprofloxacin Suppository on Inflammatory Reaction and Oxidative Stress in Patients with Bacterial Vaginitis

目的 研究硝呋太尔联合环丙沙星栓治疗细菌性阴道炎的临床疗效。方法 回顾性分析晋江市妇幼保健院2021年7月—2022年7月收治的75例细菌性阴道炎患者的临床资料,按照治疗方案分为对照组37例和研究组38例。对照组单用环丙沙星栓进行治疗,研究组在环丙沙星栓基础上联合硝呋太尔进行治疗。比较两组各项症状缓解时间和炎症反应[Toll样受体2(tolllikereceptor 2,TLR2)、白介素-4(interleukin-4,IL-4)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-6(interleukin-6,IL-6)、白介素-8(interleukin-8,IL-8)、白介素-13(interleukin-13,IL-13)]、氧化应激[一氧化氮(nitric oxide,NO)、内皮素-1(endothelin-1,ET-1)、超氧化物歧化酶(superoxidedismutase,SOD)、丙二醇(malondi-aldehyde,MDA)、谷胱甘肽过氧化物酶(phospholipid hydroperoxide glutathione peroxidase,GSH-Px)、晚期氧化蛋白产物(advanced oxidation protein products,AOPPs)]指标变化情况。结果 研究组各项症状缓解时间均较对照组短,差异有统计学意义(P<0.05)。两组治疗14 d后,TLR2、IL-4、TNF-α、ET-1、IL-6、IL-8、IL-13、MDA、AOPPs水平均降低,且研究组低于对照组;而NO、SOD、GSH-Px水平升高,且研究组高于对照组,差异有统计学意义(P<0.05)。结论 硝呋太尔联合环丙沙星栓治疗细菌性阴道炎疗效确切,可有效缓解各项症状,减轻炎症反应,抑制氧化应激,值得推广应用。

Objective To study the clinical efficacy of nifurtel combined with ciprofloxacin suppository in the treatment of bacterial vaginitis.Methods The clinical data of 75 patients with bacterial vaginitis admitted to Jinjiang Maternal and Child Health Hospital from July 2021 to July 2022 were analyzed,retrospectively.All patients were divided into the control group(n=37)and the research group(n=38).The patients in control group were treated with ciprofloxacin suppository alone,while the patients in research group were treated with nifurtel on the basis of ciprofloxacin suppository.The time of symptom relief,inflammatory response[Toll like receptor 2(TLR2),interleukin-4(IL-4),tumor necrosis factor-α(TNF-α),Interleukin-6(IL-6),IL-8(IL-8),IL-13(IL-13)],and changes of oxidative stress[nitric oxide(NO),endothelin 1(ET-1),superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px),advanced oxidation protein products(AOPPs)before and after treatment between the two groups were compared.Results The remission time of all symptoms in the research group was significantly shorter than that in the control group(P<0.05).After 14 days of treatment,the levels of TLR2,IL-4,TNF-α,ET-1,IL-6,IL-8,IL-13,MDA and AOPPs] in both groups were significantly decreased,and these indexes in the research group were significantly lower than the control group.The levels of NO,SOD and GSH-Px were significantly increased in both groups,and these indexes in the research group were significantly higher than control group(P<0.05).Conclusion Nifurtel combined with ciprofloxacin suppository has a definite effect in the treatment of bacterial vaginitis,which can effectively relieve symptoms,reduce inflammatory reaction,and inhibit oxidative stress.