摘要
Nowadays,Zinc(Zn)-based biocomposites as biodegradable implant materials have been recognized as a promising approach to overcome the insufficient mechanical performance of Zn matrix and to endow the Zn-based materials with biofunctionality.However,the strengthening effect on Zn-based matrix compos-ite remains far from expectation mainly due to the poor interfacial bonding between the reinforcement and Zn matrix,and the relatively coarse grain size of the Zn matrix.Herein,we have developed a novel in situ wetting strategy to ameliorate the interfacial bonding and mechanical performance of Zn-Ag-based composites using cuprous oxide-modified graphene oxide(Cu_(2)O-GO)sheets as reinforcement.The en-hanced interfacial bonding between GO sheets and Zn matrix owing to the in situ generated ZnO inter-layer and the ultrafine microstructure with an average grain size of 360 nm were simultaneously achieved in the hot extruded(HEed)1 wt%Cu_(2)O-GO/Zn-2 wt%Ag biocomposites.Consequently,HEed biocompos-ites possessed excellent tensile properties,including ultimate tensile strength(UTS)of 344.0±2.4 MPa,yield stress(YS)of 314.0±4.8 MPa,and elongation at failure of 15.5%±1.3%.Ultrafine and uniform microstructure of the HEed biocomposites resulted in a relatively uniform corrosion morphology and a degradation rate of 0.195±0.004 mm y^(−1) in simulated body fluid(SBF)solution.The 2-fold diluted extract of the HEed biocomposites exhibited satisfying cytocompatibility with MC3T3-E1 pre-osteoblast comparable to that of Ti-6Al-4 V ELI alloys.More importantly,the synergistic effect of metallic ions,Ag-rich nanoparticles,and GO sheets contributed to the remarkable antibacterial activity of the experimental biocomposites against both S.aureus and E.coli.These results demonstrated that the 1Cu_(2)O-GO/Zn-2Ag biocomposites should be anticipated as a promising biodegradable material for orthopedic applications.
基金
This work was financially supported by the Tianjin Natural Sci-ence Foundation(Nos.20JCQNJC00610 and 20JCYBJC00620)
the National Natural Science Foundation of China(Nos.51871166 and U1764254).
