特殊医学用途食品在非酒精性脂肪性肝病干预中的应用前景

Application prospect of special medical food in non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)已成为全球最常见的肝病,截至目前,美国食品和药物管理局没有批准任何针对NAFLD的疗法。最新诊疗指南认为,NAFLD患者治疗的首要目标是减轻体重,饮食干预是其治疗的主要手段。患者自主调整日常饮食往往不能兼顾营养与治疗,不科学的节食和减脂可加重脂肪肝进展。特殊医学用途食品(FSMP)的出现及在糖尿病、胃肠道疾病等慢性病中的成功应用均表明其对疾病的治疗具有辅助作用,研发一款NAFLD相关的FSMP产品将会给患者带来更多的福音。该文综述了FSMP的发展现状,总结了NAFLD相关的FSMP的研究现状,探讨了FSMP与常规饮食干预相比的优点,以期为未来NAFLD相关的FSMP研制及应用提供理论基础。

Non-alcoholic fatty liver disease(NAFLD)has become the most common liver disease worldwide.To date,the US Food and Drug Administration has not approved any treatment for NAFLD.According to the latest diagnosis and treatment guidelines,the primary goal of treatment for NAFLD patients is to lose weight,and dietary intervention is the main means of treatment.The patients can not take into account the nutrition and treatment of daily diet adjustment,unscientific diet and fat reduction can aggravate the progress of fatty liver.The emergence of food for special medical purpose(FSMP)and its successful application in diabetes and other chronic diseases show that it plays an auxiliary role in the treatment of diseases.The development of a FSMP for NAFLD will bring more benefits to the patients.This paper reviewed the development status of FSMP and analyzed the research status of FSMP related to NAFLD,explored the advantages of FSMP compared to conventional dietary interventions,in order to provide theoretical reference for the development and application of NAFLD FSMP in the future.