光学相干断层扫描血管成像在神经系统疾病中的应用研究进展

Application of optical coherence tomography angiography in nervous system diseases

血脑屏障是人体重要的保护机制之一,在维持中枢神经系统稳态方面发挥着至关重要的作用,因此,现在普遍认为,血脑屏障功能紊乱是许多神经系统疾病发生的潜在危险因素。神经系统相关检查方法由于其侵入性和高成本,未能使其在疾病的筛查中得到广泛使用,仍然需要寻找经济、非侵入性、精确的早期标记进行筛查。由于视网膜和脑血管系统在胚胎发育及生理和解剖特征方面相似,通过研究眼内血管结构以了解脑血管系统成为近年来研究热点。

The blood-brain barrier is one of the important protective mechanisms of the human body and plays a vital role in maintaining the stability of the central nervous system.Therefore,it is generally believed that the dysfunction of the blood-brain barrier is a potential risk factor for many nervous system diseases.Because of its invasion and high cost,the relevant examination methods of the nervous system have not been widely used in the screening of diseases.It is still necessary to find economic,non-invasive and accurate early markers for screening.Because the retina and cerebral vascular system are similar in embryonic development,physiological and anatomical characteristics,it has become a research hotspot in recent years to understand the cerebral vascular system by studying the structure of intraocular blood vessels.