NLRP3炎性小体与糖尿病心肌病的研究进展

NLRP3 inflammasome and diabetic cardiomyopathy

糖尿病心肌病(DCM)是由糖尿病导致的特异性心脏病,独立于其他心血管疾病。关于DCM的发病机制尚不十分明确,研究发现,炎症在DCM的发生、发展过程中起到了重要作用。随着NLRs家族的发现,NLRP3炎性小体与DCM的研究越来越多。大量证据表明NLRP3能够介导促炎因子的释放和细胞焦亡,参与DCM的病理生理过程。本文就NLRP3炎性小体的基本知识、NLRP3与DCM的关系以及DCM中靶向NLRP3的治疗药物进行系统综述。

Diabetic cardiomyopathy(DCM)is a specific heart disease caused by diabetes,and is independent from other cardiovascular diseases.The pathogenesis of DCM is not very clear.Studies have found that inflammation plays an important role in the occurrence and development of DCM.With the discovery of NLRs family,more and more studies have been conducted on NLRP3 inflammasome and DCM.A large amount of evidence suggests that NLRP3 is involved in the pathophysiological process of DCM by mediating the release of pro-inflammatory factors and pyrodeath of cells.In this article,we systematically review the basic knowledge of NLRP3 inflammatories,the relationship between NLRP3 and DCM,and the therapeutic drugs targeting NLRP3 in DCM.