空气污染物诱导肺(呼吸)毒性的表观遗传机制研究进展

Research Progress on the Epigenetic Mechanisms of Lung(Respiratory)Toxicity Induced by Air Pollutants

诱发肺(呼吸)毒性/疾病是空气污染物暴露对人类健康的主要威胁。表观遗传修饰与肺(呼吸)功能密切相关,其在空气污染物暴露致肺(呼吸)毒性中的作用机制已引起广泛关注。该文综述了颗粒物、香烟烟雾、柴油机尾气及其他空气污染物通过调控表观遗传修饰(DNA甲基化、组蛋白修饰、ncRNAs等)诱导肺(呼吸)毒性的机制研究进展,指出空气污染物暴露可改变生物体的表观遗传修饰特征,导致相关基因表达失调、炎症反应、细胞凋亡、DNA损伤,从而诱发一系列肺(呼吸)毒性/疾病,并总结目前研究中存在的不足,提出未来研究方向的建议,希望为后续相关研究提供参考。

Induction of lung(respiratory)toxicity/disease is the main threat of air pollutants exposure to human health.Epigenetic modifications are closely related to lung(respiratory)function,and their mechanism of action in lung(respiratory)toxicity caused by air pollutants has attracted extensive attention.This paper reviews the research progress on the mechanism of lung(respiratory)toxicity induced by air pollutants such as particulate matters,cigarette smoke and diesel exhaust particles through the regulation of epigenetic modifications(DNA methylation,histone modifications,and ncRNAs),and it is concluded that air pollutant exposure can alter the epigenetic modification characteristics of organisms and lead to the dysregulation of related gene expression,inflammation,cell apoptosis and DNA damage,thus inducing a series of lung(respiratory)toxicity or diseases.In addition,the shortcomings of the current researches and the future research directions was proposed,hoping to provide references for subsequent relevant studies.