肺炎克雷伯菌、类肺炎克雷伯菌和变栖克雷伯菌的研究进展

Advance in Klebsiella pneumoniae, Klebsiella quasipneumoniae and Klebsiella variicola

肺炎克雷伯菌临床分离株是一种有荚膜的革兰阴性粗短杆菌,是临床上重要的机会致病菌。肺炎克雷伯菌临床分离株基因间存在差异,依据系统发育树可分为肺炎克雷伯菌(Klebsiella pneumoniae,KpⅠ)、类肺炎克雷伯菌(Klebsiella quasipneumoniae,KpⅡ)和变栖克雷伯菌(Klebsiella variicola,KpⅢ),三者生态分布、基因型、耐药性、毒力特征以及致病性存在显著差异,为感染性疾病精准治疗带来新的挑战。本文对KpⅠ、KpⅡ、KpⅢ的鉴定、流行特点及致病特点的最新研究进展进行综述。

The clinically isolated Klebsiella pneumoniae(K.pneumoniae),a rod-shaped Gram-negative bacteria with capsular,is an important opportunistic pathogen in clinic.There are genetic differences among clinical isolates of K.pneumoniae.Strains can be divided into K.pneumoniae(KpⅠ),K.quasipneumoniae(KpⅡ)and K.variicola(KpⅢ)three groups according to the phylogenetic tree.There are significant differences in ecological distribution,genotype,drug resistance,virulence characteristics,and pathogenicity among this three groups,which brings new challenges to the precise treatment of infectious diseases.In this article,the latest studies of identification,epidemic characteristics and pathogenic characteristics of K.pneumoniae,K.quasipneumoniae and K.variicola are reviewed.