胃肠道肌层巨噬细胞在胃肠运动调节中的作用

Role of Gastrointestinal Muscularis Macrophages in Regulation of Gastrointestinal Motility

近年研究在胃肠道发现了一类特殊的巨噬细胞肌层巨噬细胞(MMs),其可与肠神经元(EN)、Cajal间质细胞(ICC)、平滑肌细胞(SMC)等相互作用,共同维持肠道运动功能。在肠道菌群改变、炎症或应激状态下,MMs可发生表型等变化,通过多种机制作用于EN、ICC或SMC,最终影响胃肠运动功能。本文就胃肠道MMs调节胃肠运动的机制及其在胃肠运动障碍性疾病中的作用作一综述。

Recent studies have found a special class of macrophages,muscularis macrophages(MMs),in the gastrointestinal tract,which interacts with enteric neuron(EN),interstitial cells of Cajal(ICC),and smooth muscle cells(SMC)to maintain normal intestinal motility.MMs can undergo phenotypic and other changes under altered intestinal microbiota,inflammation,or stress,and act on EN,ICC,or SMC through multiple mechanisms,ultimately affecting gastrointestinal motility.This article reviewed the mechanism of gastrointestinal MMs regulating gastrointestinal motility and role in gastrointestinal motility disorder diseases.