碳青霉烯类耐药铜绿假单胞菌耐药机制与治疗现状

Resistance mechanism and treatment of carbapenem resistant Pseudomonas aeruginosa

铜绿假单胞菌是院内感染常见的条件致病菌,其在医院的环境中分布较广且可长期存活。碳青霉烯类抗生素在治疗铜绿假单胞菌导致的严重感染中起重要作用,但近年来碳青霉烯类耐药铜绿假单胞菌的暴发尤其突出,这给临床治疗带来极大挑战。文章介绍铜绿假单胞菌对碳青霉烯类抗生素的多种耐药机制,总结目前临床上应用的各种治疗方案,为临床合理用药和科学防治碳青霉烯类耐药铜绿假单胞菌感染提供可参考的思路。

Pseudomonas aeruginosa is a common opportunistic pathogen of nosocomial infection,which is widely distributed in the hospital environment and can survive for a long time.Carbapenems antibiotics play an important role in the treatment of serious infections caused by Pseudomonas aeruginosa.However,the outbreak of carbapenems resistant Pseudomonas aeruginosa is particularly prominent in recent years,which has made clinical treatment facing great challenges.This article introduces the main resistance mechanism of Pseudomonas aeruginosa to carbapenems antibiotics and summarizes the application of various clinical treatment schemes,and provides a reference clinical rational use of antibiotics and treatment of carbapenems resistant Pseudomonas aeruginosa infection.