儿童心脏标志物检测的临床意义

Role of cardiac markers in children

近年来,越来越多的研究证实了心脏标志物在不同疾病儿童患者中的诊断价值和临床应用前景,在心肌炎、心肌病、先天性心脏病(CHD)和心力衰竭等儿童心源性疾病的诊断和预后评估中有重要的临床意义,在判断儿童免疫相关和其他全身性疾病导致的心脏功能、心肌损伤程度,预测并发症和诊疗效果方面的研究也有新进展。由于儿童各组织、器官尚处于生长发育阶段,不同年龄段儿童,尤其是新生儿,心脏标志物检测结果存在明显差异,使检测报告的解释更具挑战性。心脏标志物在儿童患者疾病诊疗中的应用需侧重于新的分析方法、不同年龄患儿检测指标参考区间的建立和更多的循证研究,发布基于循证数据的相关指南或专家共识,推动临床规范应用儿童患者心脏标志物检测结果。

In the recent years,an increasing number of studies have confirmed the diagnostic value and clinical application prospects of cardiac markers in different diseases,such as myocarditis,cardiomyopathy,congenital heart disease(CHD)and heart failure among children.In addition,it has made new progress in judging cardiac function,the degree of myocardial injury,the occurrence of complications and the effect of diagnosis and treatment of immune-related and other systemic diseases.Children's tissues and organs are still in growth and development stage,there are differences in the determination results of cardiac markers in children with different ages,especially in newborns,which makes the interpretation of determination reports more challenging.Therefore,future researches should focus on new analytical methods,the establishment of biological reference intervals for different ages and more evidence-based research in the diagnosis and treatment of children.Related guidelines or expert consensus should be issued to promote the clinical standard application of cardiac marker determination results in children.