肠道菌群调控骨代谢及中药应用研究进展

Review of bone metabolism regulated by intestinal flora and the application of Traditional Chinese Medicine

肠道菌群是定植在人体内复杂而庞大的微生物群落,肠道菌群及其代谢物短链脂肪酸在参与人体代谢、抵御外来致病菌以及调节免疫机制等方面发挥重要作用。近年来,不少研究发现肠道菌群与骨骼代谢密切相关。肠道菌群可通过营养吸收、短链脂肪酸生成、调节机体免疫、影响机体代谢等多种途径调控骨代谢,影响骨量变化。本文综述了肠道菌群影响骨代谢中骨量变化的潜在途径及作用机制,以及中药干预肠道菌群调控骨代谢的相关进展,以期为骨代谢相关疾病骨质疏松症的防治提供新思路。

As a complex and large microbial community colonized in the human body,the intestinal flora and its metabolites short-chain fatty acids(SCFAs)play an important role in participating in human metabolism,resisting pathogens,and regulating immune mechanisms.In recent years,many studies have found that the intestinal flora is closely related to bone metabolism.The intestinal flora is able to regulate bone metabolism and affect bone mass changes through various pathways such as absorption of nutrition,generation of SCFAs,regulation of immunity,and influence on body metabolism.The potential pathways and mechanisms by which intestinal flora affect bone mass changes were reviewed in this article in bone metabolism.The related study on Traditional Chinese Medicine that has effects in balancing intestinal flora for regulating bone metabolism was also introduced in order to provide new ideas for the prevention and treatment of osteoporosis,a disease related to bone metabolism.