小儿热速清颗粒联合头孢克肟治疗儿童上呼吸道感染临床研究

Clinical Study of Children Resuqing Granule Combined with Cefixime in the Treatment of Upper Respiratory Tract Infection in Children

目的 探讨小儿热速清颗粒联合头孢克肟治疗儿童上呼吸道感染的临床疗效及对炎症因子水平的影响。方法 选取2020年1月—2022年8月就诊于本院呼吸内科的80例上呼吸道感染患儿为研究对象,根据随机数字表法将患儿分为观察组和对照组,每组40例。对照组患儿给予头孢克肟治疗,观察组患儿给予头孢克肟联合小儿热速清颗粒治疗。比较2组患儿临床疗效、退热情况、临床症状改善时间以及血清C反应蛋白(C-reactive protein,CRP)、中性粒细胞百分比(neutrophil,NEU)、血小板计数(platelet count,PLT)水平。结果 治疗后,观察组患儿临床治疗总有效率显著高于对照组(P<0.05)。观察组退热起效时间、完全退热时间均显著短于对照组(P<0.05),体温复升率显著低于对照组(P<0.05)。观察组咽喉红肿、咳嗽、流涕、肺部啰音等临床症状改善时间均显著短于对照组(P<0.05)。观察组血清CRP、NEU水平显著低于对照组(P<0.05),血清PLT水平显著高于对照组(P<0.05)。结论 小儿热速清颗粒联合头孢克肟治疗上呼吸道感染患儿可显著缩短退热时间,减少体温复升,加快临床症状改善,降低炎症反应水平,提高临床疗效。

Objective To investigate the clinical efficacy of children Resuqing granule combined with cefixime in the treatment of children's upper respiratory tract infection and its influence on the levels of inflammatory factors.Methods Eighty children with upper respiratory tract infection who went to the respiratory department of our hospital from January 2020 to August 2022 were selected as the research objects.According to the random number table,the children were divided into observation group and control group,with 40 cases in each group.The children in the control group were treated with cefixime,and the children in the observation group were treated with cefixime combined with children Resuqing granules.The clinical efficacy,fever relief,duration of symptom improvement,and levels of serum C-reactive protein(CRP),neutrophil percentage(NEU),and platelet count(PLT)were compared between two groups of children.Results After treatment,the total effective rate of clinical treatment in the observation group was significantly higher than that in the control group(P<0.05).The onset time and complete antipyretic time in the observation group were significantly shorter than those in the control group(P<0.05),and the rate of body temperature recovery was significantly lower than that in the control group(P<0.05).The improvement time of clinical symptoms such as sore throat,cough,runny nose,and lung rale in the observation group were significantly shorter than those in the control group(P<0.05).The levels of serum CRP and NEU in the observation group were significantly lower than those in the control group(P<0.05),while the levels of serum PLT were significantly higher than those in the control group(P<0.05).Conclusion Children Resuqing granules combined with cefixime in the treatment of children with upper respiratory tract infection could significantly shorten the antipyretic time,reduce the temperature rise,speed up the improvement of clinical symptoms,reduce the level of inflammatory reaction,and improve the clinical efficacy.