丙酸氟替卡松联合孟鲁司特钠治疗慢性咳嗽患儿的临床效果及其对CRP、IgE水平的影响

Clinical Effect of Fluticasone Propionate Combined with Montelukast Sodium in the Treatment of Children with Chronic Cough and Its Impact on CRP and IgE Levels

目的探讨丙酸氟替卡松联合孟鲁司特钠治疗慢性咳嗽患儿的临床效果及对C反应蛋白(CRP)、免疫球蛋白E(IgE)水平的影响。方法86例慢性咳嗽患儿随机分为两组,对照组采用孟鲁司特钠治疗,观察组采用孟鲁司特钠联合丙酸氟替卡松治疗,比较两组的治疗效果及治疗前后的CRP、IgE水平。结果观察组的治疗总有效率为90.70%,显著高于对照组的74.42%(P<0.05)。治疗后,两组的CRP、IgE水平均显著低于治疗前,且观察组的CRP、IgE水平均显著低于对照组(P<0.05)。结论丙酸氟替卡松联合孟鲁司特钠治疗慢性咳嗽患儿的临床效果显著,可降低患儿CRP、IgE水平。

Objective To explore the clinical effect of fluticasone propionate combined with montelukast sodium in the treatment of children with chronic cough and its impact on C-reactive protein(CRP)and immunoglobulin E(IgE)levels.Methods 86 children with chronic cough were randomly divided into two groups.The control group was treated with montelukast sodium,and the observation group was treated with montelukast sodium combined with fluticasone propionate.The therapeutic effect and the levels of CRP and IgE before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 90.70%,significantly higher than 74.42%in the control group(P<0.05).After treatment,the levels of CRP and IgE in the two groups were significantly lower than those before treatment,and the levels of CRP and IgE in the observation group were significantly lower than those in the control group(P<0.05).Conclusions Fluticasone propionate combined with montelukast sodium in the treatment of children with chronic cough has significant clinical effect,and can reduce the levels of CRP and IgE of children.