摘要
干细胞治疗在医学领域发展迅速且应用日益广泛。在基础研究和临床试验中,干细胞治疗多种生殖系统疾病均显示良好效果。近年来不同来源的间充质干细胞(MSCs)在多囊卵巢综合征(PCOS)治疗中取得一系列研究进展。本文总结了MSCs及其外泌体治疗PCOS的机制,包括调节激素和糖、脂代谢,抑制炎症反应和调节免疫功能,归巢效应以及促血管生成,改善排卵与生殖潜能等。回顾了诱导多能干细胞(iPSCs)和胚胎干细胞(ESCs)在PCOS实验研究进展,为干细胞在PCOS的临床研究与应用提供探索思路。
Stem cell based therapy is rapidly developing and widely applied in medical field.Several reproductive diseases have been treated using various types of stem cells in experimental studies and clinical trials,which have produced favorable results.In recent years,some experimental research progress of mesenchymal stem cells(MSCs)derived from different sources in the treatment of polycystic ovary syndrome(PCOS)has been reported.This article reviewed the mechanism of MSCs and their exosomes in the treatment of PCOS,including regulating hormones,sugar and lipid metabolism,inhibiting inflammatory response,regulating immune function,homing effect,promoting angiogenesis,and enhancing ovulation and reproductive potential function.This review also summarized the progress of experimental research on induced pluripotent stem cells(iPSCs)and embryonic stem cells(ESCs)in PCOS and provided some exploration ideas for the clinical research and application of stem cells in PCOS.
作者
符莞孟
王晓黎
刘玉
张潍
张菊
Fu Wanmeng;Wang Xiaoli;Liu Yu;Zhang Wei;Zhang Ju(Hainan BoaoWorldlight Hospital R&D Center,Qionghai 571437,China;Hainan Province Women and Children Medical Center,Haikou 570312,China;Department of Gynecology and Obstetrics,Xijing Hospital,Air Force Medical University,Xi'an 710038,China)
出处
《中华细胞与干细胞杂志（电子版）》
2023年第2期108-114,共7页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
陕西省重点研发计划(2017ZDXM-SF-037)
全军医学科技青年培育项目(16QNP112)。
关键词
多囊卵巢综合征
间充质干细胞
外泌体
诱导多能干细胞
胚胎干细胞
Polycystic ovary syndrome
Mesenchymal stem cell
Exosome
Induced pluripotent stem cell
Embryonic stem cell
