缺氧预处理间充质干细胞的功能及机制研究进展

Advances in the function and mechanism of hypoxic preconditioned mesenchymal stem cells

间充质干细胞(MSCs)具有免疫调节、组织修复和造血等多种生物功能,获得了广泛的关注和研究,是目前再生医学领域研究的热点,但在临床应用中存在移植后存活率低以及功能发挥受限的问题。近年来,利用物理、化学和生物刺激等预处理改善MSCs生物活性的研究取得较大进展,缺氧为其中较为广泛的一种预处理方式。本文就缺氧预处理对MSCs增殖、凋亡、分化、归巢、旁分泌、促进血管生成和免疫功能的影响及机制作一综述。

Mesenchymal stem cells(MSCs)therapy is currently a hot spot in the field of regenerative medicine.It has received extensive attention and research due to its various biological activities such as immune regulation,tissue repair,and hematopoiesis.But in clinical applications,MSCs transplantation faces challenges such as low survival rates and limited functionality.In recent years,great progress has been made in improving the biological activity of MSCs by using physical,chemical and biological stimulation pretreatments,and hypoxia is one of the most widely used pretreatment methods.This article critically examines the impact and mechanisms of hypoxic preconditioning on various functions of MSCs such as proliferation,apoptosis,differentiation,homing,paracrine signaling,angiogenesis,and immune response.