二硝托胺的合成新方法

A new synthetic method for zoalene

随着全球养殖业集约化的出现,同时也带来了病害传播迅速等缺点。二硝托胺为广谱、高效、安全的抗球虫药,可以快速有效地解决家禽等集中养殖时的病害危险。经过大量的实验,得到了一种制备二硝托胺的新方法,即以邻甲基苯腈为原料,在浓硫酸中用硝酸45~50℃硝化,得到3,5-二硝基-2-甲基苯腈,然后将该中间体在90%硫酸中水解得到二硝托胺粗品,再经乙醇重结晶,得到高纯度的二硝托胺成品。该方法与现有工艺相比反应条件温和,且不再使用氯化亚砜,整个生产工艺更加安全和环保。

As the intensification of the global aquaculture industry,the drawbacks such as rapid spread of diseases were brought about.Dinitrothoramine is a broad-spectrum,efficient,and safe anti coccidian drug that can quickly and effectively solve the disease risks of poultry and other centralized farming.After a large number of experiments,a new method for preparing dinitrotropine was obtained.Using o-methylbenzonitrile as the raw material,3,5-dinitro-2-methylbenzonitrile was nitrated with nitric acid at 45~50℃in concentrated sulfuric acid to obtain 3,5-dinitro-2-methylbenzonitrile.The intermediate was then hydrolyzed in 90%sulfuric acid to obtain a crude product of dinitrotropine,which was then recrystallized in ethanol to obtain a high-purity finished product of dinitrotropine.Compared with existing processes,the method has mild reaction conditions and no longer uses sulfoxide chloride,making the entire production process safer and more environmentally friendly.