北京市人群骨退行性疾病患病及影响因素

Prevalence and associated factors of bone degenerative diseases among Beijing residents

目的在北京市人群中开展骨退行性疾病(bone degenerative diseases,BDD)研究,以了解北京市BDD人群患病情况及影响因素。方法采用方便抽样,招募自愿参与且年龄在18~<65岁的北京市常住人群进入北京BDD研究。采用问卷收集受试者的一般人口学资料,同时对受试者进行体格检查、生化检查和骨科专科体检,并开展影像学检查。运用多因素logistic回归模型分析BDD影响因素。结果共纳入879名研究对象,年龄为(39.79±9.12)岁。共有697人患有BDD,占总人数79.29%。多因素logistic回归模型分析显示,高龄人群患BDD的风险较高。与18~<35岁组相比,35~<50岁组与50~<65岁组BDD患病的OR值(95%CI)分别为2.684(1.845~3.904)与13.898(4.807~40.176)。超重和肥胖者与体质指数(body mass index,BMI)正常者相比,OR值(95%CI)分别为1.209(0.811~1.801)和1.768(1.030~3.035)。已婚者患病风险显著高于未婚/离异/丧偶者,其OR值(95%CI)为1.924(1.271~2.912)。结论北京市18~<65岁人群BDD检出率较高。应加强在已婚、高年龄段、超重和肥胖者中BDD的宣传及体检。

Objective The Beijing bone degenerative diseases(BDD)study aims to investigate the prevalence and factors associated with BDD among the population in the Beijing area.Methods We recruited the volunteers aged 18-<65 years who were residents of Beijing using convenience sampling.Participants completed a questionnaire about demographic information,and underwent physical,biochemical examinations,orthopedic examinations and imagological examination.Multivariate logistic regression was used to identify the influencing factors associated with BDD.Results A total of 879 participants with an average age of(39.79±9.12)years were included in the BDD study.A total of 697 subjects had BDD,accounting for 79.29%of the whole participants.Multivariate logistic regression analysis showed that the risk of bone degenerative diseases was higher in older age groups.Compared to the 18-<35 age group,the OR value(95%CI)for BDD were 2.684(1.845-3.904)for the 35-<50 age group,and 13.898(4.807-40.176)for the 50-<65 age group.The OR value(95%CI)of BDD in overweight and obesity participants,compared to normal BMI,were 1.209(0.811-1.801)and 1.768(1.030-3.035),respectively.Married participants had a significantly higher risk of BDD than unmarried/divorced/widowed participants,with an OR value(95%CI):1.924(1.271-2.912).Conclusions The prevalence of BDD among Beijing residents aged 18-<65 years is much higher.The promotion and physical examination of BDD should be strengthened for married,elderly,overweight and obese people.