HBV与外泌体的相关性研究进展

Recent advances in the study of HBV and exosomes

乙型肝炎病毒(Hepatitis B virus,HBV)感染导致乙型肝炎,也是我国肝细胞癌(hepatocellular carcinoma,HCC)发生最主要的危险因素,但其致病机制迄今并不完全清楚。尽管抗病毒治疗可有效抑制HBV聚合酶的活性并减缓疾病进展,但不能完全根除慢性感染者体内的HBV病毒。因此,对于HBV致病机制及其治疗仍然需要持续和深入研究。外泌体是一种细胞间物质和信息传递的载体,参与抗原提呈、免疫应答及肿瘤进展等多种生理病理过程。近年来的研究发现,外泌体在HBV的致病过程中发挥重要作用,且在HBV感染的诊断和治疗中具有重要的应用价值。本文对外泌体与HBV的相关性研究进行了综述。

Hepatitis B virus(HBV)infection leads to hepatitis B and is the most major risk factor for hepatocellular carcinoma(HCC)in China,but the pathogenesis of HCC remains unclear.Although antiviral therapy can effectively inhibit HBV polymerase activity and slow the progression of disease,HBV virus cannot be completely eradicated in patients with chronic infection.Therefore,the pathogenesis and treatment of HBV still need continuous and intensive research.Exosomes are carriers of intercellular substances and information transmission,which are involved in many physiological and pathological processes such as antigen presentation,immune response and tumor progression.Recent studies have found that exosomes play an essential role in the pathogenesis of HBV and have important application value in the diagnosis and treatment of HBV infection.This paper reviews the correlation between exosomes and HBV.