Lp-PLA2水平与急性动脉粥样硬化脑梗死患者常见危险因素的相关性分析

Correlation of Lp-PLA2 Level andCommon Risk Factors in Patients with Acute Atherosclerotic Cerebral Infarction

目的研究血浆脂蛋白相关磷脂酶A2(Lp-PLA2)和急性动脉粥样硬化脑梗死(Acute cerebral infarct,ACI)常见影响因素的关系。方法将本院2017年8月至2019年8月收治的急性动脉粥样硬化ACI患者100例纳入观察组,同期取100例健康体检者纳入对照组,收集两组基本信息,并给予Lp-PLA2、血脂指标、C反应蛋白(CRP)、同型半胱氨酸(Hcy)等实验室指标检测。比较两组实验室指标水平、既往病史与行为习惯、Lp-PLA2水平与不同亚型ACI患者Lp-PLA2水平,分析Lp-PLA2与急性动脉粥样硬化ACI常见危险因素相关性。结果两组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、纤维蛋白(Fib)相比较,差异均无统计学意义(P>0.05)。观察组高密度脂蛋白胆固醇(HDL-C)较对照组低,C反应蛋白(CRP)、同型半胱氨酸(Hcy)较对照组高,差异有统计学意义(P<0.05)。观察组糖尿病史、高血压史占比较对照组高,差异有统计学意义(P<0.05)。重型ACI组患者Lp-PLA2水平较中型、轻型ACI组高,差异有统计学意义(P<0.05)。Lp-PLA2与急性动脉粥样硬化ACI酗酒、吸烟、高血压史负相关(r=-0.271、-0.243、-0.297,P=0.003、0.002、0.002),与CRP呈正相关(r=0.297,P=0.002)。结论Lp-PLA2与急性动脉粥样硬化ACI酗酒、吸烟、高血压史、CRP存在相关性。

Objectives To investigate the relationship between plasma lipoprotein-associated phospholipase A2(Lp-PLA2)and common influencing factors of acute atherosclerotic cerebral infarction(ACI).Methods A total of 100 patients with acute atherosclerosis ACI admitted to our hospital from August 2017 to August 2019 were included in the observation group,and 100 healthy subjects were included in the control group during the same period.Basic information of the two groups was collected,and laboratory indicators such as Lp-PLA2,blood lipid index,C-reactive protein(CRP),and homocysteine(Hcy)were detected.The levels of laboratory indexes,past medical history and behavioral habits,Lp-PLA2 levels and Lp-PLA2 levels in patients with different subtypes of ACI were compared between the two groups,and the correlation between Lp-PLA2 and common risk factors of acute atherosclerosis ACI was analyzed.Results There was no significant difference in triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and fibrin(Fib)between the two groups(P>0.05).The high-density lipoprotein cholesterol(HDL-C)in the observation group was significantly lower than that in the control group,and the C-reactive protein(CRP)and homocysteine(Hcy)were significantly higher than those in the control group(P<0.05).The history of diabetes and hypertension in the observation group was significantly higher than that in the control group(P<0.05).The level of Lp-PLA2 in severe ACI group was significantly higher than that in the moderate and mild ACI groups(P<0.05).Lp-PLA2 was negatively correlated with the history of alcoholism,smoking and hypertension in ACI patients with acute atherosclerosis(r=-0.271,-0.243,-0.297,P=0.003,0.002,0.002),and positively correlated with CRP(r=0.297,P=0.002).Conclusions Lp-PLA2 is correlated with alcoholism,smoking,hypertension history and CRP in acute atheroscleroticACI.