孕早期胎儿NT筛查在产前超声筛查单胎妊娠孕妇中的价值

The value of fetal NT screening in early pregnancy in prenatal ultrasound screening of singleton pregnant women

目的探讨孕早期胎儿NT筛查在产前超声筛查单胎妊娠孕妇中的价值。方法选取2019年3月-2020年12月在云浮市中医院进行产前筛查的368例单胎妊娠孕妇,对其进行颈项透明层(NT)筛查,分析不同年龄段产妇NT增厚率;对不同NT厚度妊娠结局进行比较;并与二维彩超、早期血清学进行对比,判断NT筛查的灵敏度、特异性、准确度。结果NT<2.5mm的产妇出现不良妊娠率为2.54%,而NT增厚的产妇出现不良妊娠率高达78.57%。其中NT厚度<2.5mm组的正常胎儿占比明显高于NT增厚的三组产妇;而染色体异常、严重结构畸形、水囊状淋巴管瘤、停止发育的发生率与其他三组比较,明显更低。进而对不同年龄段单胎孕妇进行分析,>35周岁产妇NT增厚率达14.52%;≤35周岁产妇NT增厚率为1.63%,与>35周岁年龄段孕妇比较,具有显著差异(P<0.05)。NT筛查与二维彩超、血清学检查结果进行对比,发现其灵敏度、特异性、准确度都高于二维彩超,与血清学检查结果一致性较高。结论NT筛查用于单胎孕妇筛查具有较好的临床效果。

Objective To explore the value of fetal NT screening in early pregnancy in prenatal ultrasound screening of singleton pregnant women.Methods 368 pregnant women with singleton pregnancy who underwent prenatal screening in our hospital from March 2019 to December 2020 were screened for cervical transparent layer(NT),and the NT thickening rate of pregnant women at different ages was analyzed;comparison of pregnancy outcomes with different NT thickness;the sensitivity,specificity and accuracy of NT screening were compared with two-dimensional color Doppler ultrasound and early serology.Results The adverse pregnancy rate of pregnant women with NT<2.5mm was 2.54%,while the adverse pregnancy rate of pregnant women with NT thickening was as high as 78.57%.The number of normal fetuses in the group with NT thickness<2.5mm was significantly higher than that in the three groups with NT thickening;the incidence of chromosome abnormality,severe structural malformation,water cystic lymphangioma and cessation of development was significantly lower than that of the other three groups.Furthermore,we analyzed singleton pregnant women of different ages.For pregnant women over 35 years old,the thickening rate of NT was 14.52%;the thickening rate of NT in pregnant women under 35 years old was 1.63%,which was significantly different from that in pregnant women over 35 years old(P<0.05).NT screening was compared with twodimensional color Doppler ultrasound and serological examination results.It was found that its sensitivity,specificity and accuracy were higher than two-dimensional color Doppler ultrasound,and had high consistency with serological examination results.Conclusion NT screening for singleton pregnant women has a good clinical effect.