基于数据挖掘的中医药治疗小儿湿疹组方用药规律研究

Medication Rules of Traditional Chinese Medicine for Treating Eczema in Children Based on Data Mining

目的:通过应用中医传承辅助平台(V 2.5)挖掘中医药治疗小儿湿疹的组方用药规律,并对高频药物、用药模式及治疗思路进行探讨。方法:搜集国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)及中文科技期刊数据库(CCD)中2000—2021年应用中医药治疗小儿湿疹的相关文献,经过筛选后建立方药数据库,运用中医传承辅助平台(V 2.5)集成的改进互信息法、关联规则Apriori算法、复杂系统熵聚类与无监督熵聚类等算法对药物频次、性味归经、用药模式、规则分析及新处方等结果进行输出,并进行网络可视化展示。结果:纳入处方200首,共涉及206味中药,高频药物包括甘草、白鲜皮、薏苡仁、茯苓、生地黄、金银花、蝉蜕、地肤子、防风、牡丹皮等,药性以寒性(52.76%)居多,药味以甘(38.89%)、苦(33.37%)、辛(21.96%)味为主,归经以胃经(1138次)、脾经(1088次)、肝经(1061次)居多,并且得到药物之间的关联规则,以及新处方6个。结论:小儿湿疹用药以补虚药、利水渗湿药、清热药、清热解毒药、解表药为主,治疗以疏风清热,燥湿健脾,养血活血为主要大法,分析结果与本病诊疗指南较为吻合,可为小儿湿疹的临床治疗及新药开发提供参考。

Objective:To explore the medication rules of traditional Chinese medicine(TCM)prescriptions for treating eczema in children by the application of the Traditional Chinese Medicine Inheritance Support System(TCMISS,V 2.5),and to analyze the high-frequency medicines,medication patterns,and treatment ideas.Methods:The articles about the TCM treatment of eczema in children were retrieved from China National Knowledge Infrastructure(CNKI),China Science Periodical Database(CSPD),and Chinese Citation Database(CCD)with the time interval from 2000 to 2021.The articles screened out were used to establish a prescription database.The improved mutual information method,Apriori algorithm,complex system entropy clustering,and unsupervised entropy clustering in TCMISS(V 2.5)were employed to analyze the medicine frequency,nature,taste,and meridian tropism,medication patterns and rules,and new prescriptions,and the results were visualized in networks.Results:A total of 200 prescriptions were included,involving 206 Chinese medicines.High-frequency medicines included Glycyrrhizae Radix et Rhizoma,Dictamni Cortex,Coicis Semen,Poria,Rehmanniae Radix,Lonicerae Japonicae Flos,Cicadae Periostracum,Kochiae Fructus,Saposhnikoviae Radix,Moutan Cortex.Most of the medicines had cold nature(52.76%),sweet(38.89%),bitter(33.37%),and pungent(21.96%)tastes,and tropism to the stomach meridian(1138),spleen meridian(1088),liver meridian(1061).The association rules between medicines and 6 new prescriptions were mined out.Conclusion:The eczema in children is mainly treated with tonics,damp-draining diuretics,heat-clearing medicinals,heat-clearing and detoxicating medicinals,and exterior-releasing medicinals.The treatment methods mainly follow the principles of clearing heat and dispersing wind,drying dampness and invigorating spleen,tonifying and activating blood.The results are consistent with expert consensus and can provide a reference for the clinical treatment and drug development for eczema in children.