头孢哌酮钠舒巴坦钠不同给药方式治疗老年绿脓杆菌肺炎的临床效果观察

Clinical effect observation of different administration modes of cefoperazone sodium and sulbactam sodium in the treatment of elderly patients with pseudomonas aeruginosa pneumonia

目的观察头孢哌酮钠舒巴坦钠不同给药方式治疗老年绿脓杆菌肺炎(PAP)的效果。方法80例老年绿脓杆菌肺炎患者,根据头孢哌酮钠舒巴坦钠给药方式不同分成观察组和对照组,每组40例。对照组给予头孢哌酮钠舒巴坦钠静脉滴注治疗,观察组给予头孢哌酮钠舒巴坦钠静脉微量泵泵注治疗。比较两组患者的治疗效果、炎症反应指标[C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-8]、实验室指标[降钙素原(PCT)、D-二聚体(D-D)]与免疫功能指标[CD3^(+)、CD4^(+)/CD8^(+)、自然杀伤细胞(NK细胞)百分比]水平。结果观察组患者治疗总有效率97.50%高于对照组的82.50%,差异有统计学意义(P<0.05)。观察组患者CRP(7.07±3.96)mg/L、TNF-α(1.24±0.65)μg/L、IL-6(0.40±0.05)ng/L、IL-8(19.29±1.07)μg/L均低于对照组的(12.96±4.29)mg/L、(1.57±0.71)μg/L、(0.51±0.07)ng/L、(23.37±1.09)μg/L,差异有统计学意义(P<0.05)。观察组患者PCT(0.74±0.38)ng/ml、D-D(0.51±0.18)mg/L均低于对照组的(2.01±0.54)ng/ml、(0.72±0.23)mg/L,CD3^(+)(53.96±7.65)%、CD4^(+)/CD8^(+)(1.37±0.31)、NK细胞百分比(34.96±3.82)%均高于对照组的(50.87±7.12)%、(1.12±0.28)、(29.65±3.14)%,差异具有统计学意义(P<0.05)。结论通过持续静脉微量泵泵注头孢哌酮钠舒巴坦钠治疗老年绿脓杆菌肺炎,治疗效果更加优良,实验室各项指标都得到显著改善,值得临床广泛应用。

Objective To observe the effect of different administration modes of cefoperazone sodium and sulbactam sodium in the treatment of elderly patients with pseudomonas aeruginosa pneumonia(PAP).Methods A total of 80 elderly patients with pseudomonas aeruginosa pneumonia were divided into observation group and control group according to different administration methods of cefoperazone sodium and sulbactam sodium,with 40 cases in each group.The conventional group was given intravenous drip of cefoperazone sodium and sulbactam sodium,and the observation group was given intravenous micropump of cefoperazone sodium and sulbactam sodium.Both groups were compared in terms of therapeutic effect,inflammatory response index[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin(IL-6),IL-8],laboratory index[procalcitonin(PCT),D-dimer(D-D)]and immune function index[CD3^(+),CD4^(+)/CD8^(+),natural killer(NK)cell percentage].Results The total effective rate of 97.50%in the observation group was higher than that of 82.50%in the conventional group,and the difference was statistically significant(P<0.05).In the observation group,CRP was(7.07±3.96)mg/L,TNF-αwas(1.24±0.65)μg/ml,IL-6 was(0.40±0.05)pg/ml,and IL-8 was(19.29±1.07)pg/ml,which were lower than those of(12.96±4.29)mg/L,(1.57±0.71)μg/ml,(0.51±0.07)pg/ml,and(23.37±1.09)pg/ml in the control group,and the differences were statistically significant(P<0.05).PCT of(0.74±0.38)ng/ml and D-D of(0.51±0.18)mg/L in the observation group were lower than those of(2.01±0.54)ng/ml and(0.72±0.23)mg/L in the control group;the observation group had CD3^(+)of(53.96±7.65)%,CD4^(+)/CD8^(+)of(1.37±0.31)and NK cell percentage of(34.96±3.82)%,which were higher than those of(50.87±7.12)%,(1.12±0.28)and(29.65±3.14)%in the control group;all the differences were statistically significant(P<0.05).Conclusion Continuous intravenous micropump of cefoperazone sodium and sulbactam sodium into the body can play a better role in the treatment of elderly pseudomonas aeruginosa pneumonia,all the laboratory indexes are improved significantly,which is worthy of wide clinical application.