摘要
[Objectives] To study the coating process of paeonol sustained release pills by extrusion-spheronization method taking ethyl cellulose as the coating material. [Methods] Paeonol pills were made by Auari AW-95 Full Automatic Pill Making Machine. Coating of paeonol sustained release pills was prepared by Auari Mini Pill Polishing Machine. The prescription and process factors of paeonol sustained release pills coating were investigated by single factor experiment and orthogonal experiment. The release of paeonol sustained release pills was determined according to the cumulative release curve of paeonol. [Results] The prepared paeonol sustained release pills released slowly within 24 h, and the release rate reached 80% in 12 h. [Conclusions] The prepared paeonol sustained release pills basically meet the 24 h sustained release standard, and can be further developed and applied.
基金
Supported by National Natural Science Foundation of China(81560659)
Science and Technology Research Project of Jiangxi Provincial Department of Education(GJJ201219,GJJ2200903)
National College Students Innovation and Entrepreneurship Training Program(202210412022)
Science and Technology Plan of Jiangxi Provincial Health Commission(202211411).
