中老年慢性精神分裂症患者不同体质量指数与高敏C反应蛋白的相关性

Correlation between different body mass index and high sensitivity C-reactive protein in middle-aged and elderly patients with chronic schizophrenia

目的:探讨中老年慢性精神分裂症住院患者不同体质量指数(BMI)与高敏C反应蛋白(HsCRP)的相关性。方法:选取符合入组标准的182例慢性精神分裂症患者,收集社会人口学资料及血液学指标等临床病例资料。结果:总体患者消瘦的发生率为7.7%(14/182),超重或肥胖的发生率为36.8%(67/182)和18.7%(34/182)。与消瘦组患者比较,肥胖组患者HsCRP水平明显增高(P<0.05)。所有患者BMI与HsCRP水平等呈正相关,且肥胖与空腹血糖、总胆固醇(TC)、三酰甘油(TG)及HsCRP水平之间呈正相关。消瘦与TC、TG水平呈负相关关系(P<0.05)。回归分析显示,高水平的TG与HsCRP是精神分裂症患者肥胖的独立危险因素。结论:中老年慢性精神分裂症患者的消瘦率及肥胖率较一般人群或首发未服药的患者均较高,肥胖与HsCRP水平具有相关性。

Objective:To investigate the correlation between different body mass index(BMI)and high sensitivity C-reactive protein(HsCRP)in middle-aged and elderly patients with chronic schizophrenia.Method:A total of 182 patients with chronic schizophrenia who met the inclusion criteria were selected and social demographic data,hematological indicators and other clinical data were collected.Results:The prevalence of underweight was 7.7%(14/182),and the prevalence of overweight or obesity was 36.8%(67/182)and 18.7%(34/182).Compared with the underweight group,the HsCRP levels in the obese group were increased.BMIs of all patients were positively correlated with HsCRP levels,and obesity was positively correlated with fasting blood glucose,total cholesterol(TC),triglyceride(TG)and HsCRP levels.Underweight was negatively correlated with TC and TG levels(P<0.05).Regression analysis showed that TG and HsCRP were risk factors for obesity in schizophrenia patients.Conclusion:The rates of underweight and obesity of middle-aged and elderly patients with chronic schizophrenia were higher than that of the general population or the first-episode drug-naive patients and obesity was correlated with the level of HsCRP.