高压氧联合替硝唑片治疗慢性牙周炎临床效果及其对牙周微生态的影响

Clinical curative effect of hyperbaric oxygen combined with tinidazole tablet on chronic periodontitis and its influences on periodontal microecology

目的:分析高压氧联合替硝唑片对慢性牙周炎(CP)患者的影响。方法:选取82例CP患者作为研究对象,按照患者接受治疗方案的不同将患者分为对照组与观察组,每组各41例。对照组予以替硝唑片治疗;观察组予以高压氧联合替硝唑片治疗,疗程均为4周。比较两组患者临床疗效、治疗前后牙周微生态、炎症反应[白细胞介素1β(IL-1β)、IL-6、肿瘤坏死因子α(TNF-α)]及不良反应发生情况。结果:观察组总有效率为92.68%,高于对照组的75.61%(P<0.05);治疗后,观察组牙周微生态指标、龈沟液IL-1β、TNF-α、IL-6均低于对照组(P<0.05);治疗期间,观察组不良反应发生率为7.32%,对照组为9.76%,两组比较差异无统计学意义(P>0.05)。结论:高压氧联合替硝唑片对CP的治疗效果确切,能有效改善患者牙周微生态,缓解炎症反应,安全性良好。

Objective:To analyze the effect of hyperbaric oxygen combined with tinidazole tablet on patients with chronic periodontitis(CP).Methods:A total of 82 patients with CP were selected as the research objects.According to different treatment methods,they were divided into control group(tinidazole tablets)and observation group(hyperbaric oxygen combined with tinidazole tablets),41 cases in each group.All were treated for 4 weeks.The clinical curative effect,peridental microecology,inflammatory response[interleukin(IL)-1β,IL-6,tumor necrosis factor(TNF)-α]and adverse reactions were compared between the two groups before and after treatment.Results:The total response rate of observation group was higher than that of control group(92.68%vs.75.61%,P<0.05).After treatment,peridental microecology indexes,levels of IL-1β,TNF-αand IL-6 in gingival crevicular fluid in observation group were lower than those in control group(P<0.05).During treatment,the incidence of adverse reactions in the observation group was 7.32%,while in the control group was 9.76%,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Curative effect of hyperbaric oxygen combined with tinidazole tablet is significant on CP,which can effectively improve periodontal microecology and relieve inflammatory response,with good safety.