摘要
PTPN11,which encodes tyrosine phosphatase Shp2,is a critical gene mediating cellular responses to hormones and cytokines.Against original prediction as tumor suppressor for tyrosine phosphatases,PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis.However,most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis.This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.
基金
funded by NIH grants R01DK075916 and R01HL096125
supported by Chinese National Key Project(2012ZX10002-009,011,013)
National Natural Science Foundation of China(Grant Nos.30921006,30900770)
Key Basic Science Foundation of Shanghai(10JC1418500)
Project of the State Key Laboratory of Shanghai Jiaotong University(91-10-02).
