摘要
This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma(HCC)with hepatitis B virus(HBV)infection.We conducted a population-based,case-control study enrolling 630 Han Chinese people in Hubei province.Subjects included primary HCC patients with HBV infection(n=210),chronic hepatitis B cases(n=210)and healthy Han Chinese(n=210).-1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)and sequencing analysis.We found-1195A allele carriers had a higher risk of HCC with HBV infection(OR,0.72;95%CI,0.548–0.946).The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.
基金
supported by the National Natural Science Foundation of China(Grant No.30872237)
the Special Funds for State Key Development Program for Basic Research of China(973 Program)(No.2007CB512903).