摘要
The aim of this paper is to investigate the relationship between hepatitis B virus(HBV)DNA levels during the course and the progression to cirrhosis with chronic hepatitis B.A total of 239 chronic hepatitis B patients confirmed by liver biopsy between 2001 and 2007 were followed up for a median of 28 months.Compared with the patients without cirrhosis,the patients progressed to cirrhosis were older and with higher HBV-DNA levels at end point.However,there was no significant difference in cirrhosis progression between different HBV-DNA groups at baseline(P=0.531).Kaplan-Meier analysis showed higher HBV-DNA level at endpoint had increasing risk of cirrhosis(P=0.019).The results of Cox model indicated that HBV-DNA levels at endpoint,stage offibrosis,negative hepatitis B e antigen,andγ-glutamyl transpepti-dase at baseline were independent risk factors of cirrhosis.The relative risk ratios were 1.898,1.918,8.976,and 1.006,respectively.Progression to cirrhosis in chronic hepatitis B patients is correlated with HBV-DNA levels during follow-up.
