基于“脑肠轴”理论探讨“上下交损,当治其中”在阿尔茨海默病中的应用

On the application of"When the upper jiao and the lower jiao both impair,treat the middle jiao"in the treatment of Alzheimer's disease based on the theory of"brain-gut axis"

脑肠轴理论通过调控肠道微生物及其代谢产物与中枢神经系统相互作用对阿尔茨海默病起到干预作用,“上下交损,当治其中”通过治疗中焦郁闭使脑髓为代表的上焦与以肾精为代表的下焦盛衰既济,二者殊途同归,从不同角度阐述阿尔茨海默病的发病机制。解毒益智方作为该理论的临床应用,是中西医结合治疗阿尔茨海默病具体体现,也为中西医结合在脑病病理机制进展和新药研发奠定坚实的基础。本文将脑肠轴理论与“上下交损,当治其中”相结合,以从中西医结合角度探讨阿尔茨海默病的发病机制与治疗手段。

The brain-gut axis theory plays an intervention role in Alzheimer's disease by regulating the interaction between intestinal microorganisms and their metabolites with the central nervous system,while the concept of"When the upper jiao and the lower jiao both impair,treat the middle jiao"refers to curing the upper jiao and the lower jiao,represented by the brain marrow and the kidney essence respectively,by treating the stagnation of the middle jiao.The two theories lead to the same goal,elaborating the pathogenesis of Alzheimer's disease from different angles.Jiedu Yizhi Formula,a clinical application of this theory,specifically embodies the treatment of Alzheimer's disease with integrated traditional Chinese and western medicine,which also lays a solid foundation for the future research of pathological mechanism of encephalopathy and the research and development of new drugs in integrated traditional Chinese and western medicine.This paper integrates the two theories to explore the pathogenesis and treatment methods of Alzheimer's disease from the perspective of integrated traditional Chinese and western medicine.