血清ADMA、H-FABP水平变化与H型高血压合并冠心病患者Gensini评分的相关性

Correlations between serum ADMA,H-FABP levels and Gensini score in patients with type H hypertension complicated with coronary heart disease

目的:探讨H型高血压(HH)合并冠心病(CHD)患者血清中非对称性二甲基精氨酸(ADMA)、心型脂肪酸结合蛋白(H-FABP)水平,分析其水平变化与Gensini评分的相关性。方法:选取2020年2月-2021年1月本院收治的102例HH患者为研究对象,依据冠脉造影(CAG)结果分为合并CHD75例(设为研究组)、未合并CHD27例(设为对照组)。分析两组、不同冠脉病变支数、不同Gensini评分(轻度狭窄、中度狭窄、重度狭窄)患者血清ADMA、H-FABP水平,分析其与Gensini评分、冠脉狭窄程度、病变支数相关性。ROC分析血清ADMA、H-FABP水平对CHD-HH的预测价值。结果:与对照组比较,研究组血清ADMA、H-FABP水平升高,Gensini评分增高(P<0.05);血清ADMA、H-FABP水平随着冠脉狭窄程度、病变支数增加而升高(P<0.05);ADMA、H-FABP水平与Gensini评分、冠脉狭窄程度、病变支数呈正相关(P<0.05);联合检测CHD-HH的AUC(0.936)大于单项检测(0.743、0.802)(P<0.05)。结论:CHD-HH患者血清ADMA、H-FABP水平升高,且与冠脉病变程度有关,可用于指导HH患者CHD的防治。

Objective:To investigate the serum levels of asymmetric dimethylargine(ADMA)and heart type fatty acid binding protein(H-FABP)in patients with type H hypertension(Hh)complicated with coronary heart disease(CHD),and analyze the correlation between the changes of ADMA and H-FABP and Gensini score.Methods:102 patients with HH admitted to our hospital from February 2020 to January 2021 were selected as the study subjects.According to the results of coronary angiography(CAG),they were divided into 75 patients with CHD(set as the study group)and 27 patients without CHD(set as the control group).The levels of serum ADMA and H-FABP in patients with different coronary artery disease branches and diferent Gensini scores(mild stenosis,moderate stenosis and severe stenosis)were analyzed in the two groups,and the correlation with Gensini score,coronary stenosis degree and lesion branches was analyzed.ROC was used to analyze the predictive value ofserum ADMA and H-FABP levels for chd-hh Results:Compared with the control group,the levels of serum ADMA,H-FABP and Gensini score in the study group increased(P<0.05);The levels of serum ADMA and H-FABP increased with the degree of coronary stenosis and the number oflesion branches(P<0.05);The levels of ADMA and H-FABP were positively correlated with Gensini score,the degree of coronary stenosis and the number of lesion branches(P<0.05);The AUCofcombined detection ofchd-hh(0.936)was higherthan that of single detection(0.743,0.802)(P<0.05).Conclusion:The levels of serum ADMA and H-FABP in patients with chd-hh increased,which are related to the degree of coronary artery disease,and can be used to guide the prevention and treatment of CHD in patients with HH.