心脏淋巴系统与心肌梗死后心肌修复的研究进展

Research progress in the cardiac lymphatic system and myocardial repair after myocardial infarction

心脏淋巴系统在心肌损伤后修复过程中发挥重要作用,其可能通过维持体液稳态和控制炎症反应来调控正常组织稳态和自然再生。心脏淋巴系统在心肌损伤后激活并参与心脏疤痕形成进程。近年来关于心脏淋巴系统和心肌修复的研究逐渐增多,通过多种动物模型在淋巴管生成和淋巴管内皮细胞分泌机制阐述了心肌修复再生。深入了解心脏淋巴系统的结构、分子和功能特征有助于开发针对心脏淋巴系统的靶向治疗方案。心肌修复机制和心脏淋巴管系统相关的靶点研究有助于为心肌梗死后心肌修复治疗提供潜在的新靶点、新策略。

The lymphatic system of the heart plays an important role in the repair process after myocardial injury and may regulate normal tissue homeostasis and natural regeneration via maintaining fluid homeostasis and controlling the inflammatory response.The lymphatic system in the heart is activated after myocardial injury and is involved in the scarring process of the heart.Recent studies on the lymphatic system and myocardial repair of the heart have developed rapidly,and the mechanisms for lymphangiogenesis and lymphatic endothelial cell secretion have been elucidated by different animal models.A deep understanding of the structural,molecular,and functional characteristics of the lymphatic system of the heart can help develop therapies that target the lymphatic system in the heart.Summarizing the progress in studies on targets related to myocardial repair and the cardiac lymphatic system is helpful to provide potential new targets and strategies for myocardial repair therapy after myocardial infarction.