摘要
Sucrose char sulfonic acid efficiently catalyzed the one-pot three-component Mannich reaction of ketones,aromatic aldehydes and amines in ethanol to afford the corresponding β-amino carbonyl compounds in good to excellent yields.A series of heteroaromatic β-amino carbonyl compounds can be obtained when using 2-acetylpyrazine as substrate.This reaction can be performed under mild reaction conditions with clean reaction profiles and a simple workup procedure.
基金
The authors would like to thank the National Natural Science Foundation of China(Grant No.20572021)for funding support.
