肠道菌群/肠道微生态与心血管疾病发生的关系研究进展

Research progress on the relationship between intestinal microflora/microecology and cardiovascular disease

肠道菌群(GM)/肠道微生态(IM)在维持人体内环境稳态及维护健康方面具有重要意义。心血管疾病(CVD)是当前全球发病率及致死率均较高的一类疾病。已有研究证实,GM/IM失衡与CVD的发生及发展密切相关。GM/IM部分代谢产物也可作为CVD的生物标志物,对其进行检测或干预可能成为CVD诊断、预防或治疗的一种手段;从GM/IM层面进行临床药物代谢评价、药效评估、优效筛选也是临床药理学的一个研究方向。随着精准医学及大健康理念的推广实施,GM/IM全基因组测序及代谢组学等研究的深入,GM/IM与CVD关系的基础研究及临床应用转化也将成为今后的研究热点。本文就GM/IM与CVD的关系研究现状进行综述,旨在为CVD的防治提供诊疗思路及相关参考。

Gut microflora(GM)or intestinal microecology(IM)is of great importance in maintaining human homeostasis and health.Cardiovascular disease(CVD)is a global health burden nowadays with high morbidity and mortality,the existing research confirmed that GM/IM metabolic imbalance is closely related to the occurrence and development of CVD,and some GM/IM metabolites can also be used as biomarkers of CVD disease,and their detection or intervention becomes a possible means of diagnosis,prevention or treatment of CVD.Clinical drug metabolism and efficacy evaluation,and superior effect screening from the GM/IM level is also a research direction of clinical pharmacology.With the implementation of the concept of precision medicine and a wide health,GM/IM whole-genome sequencing and metabolomics continue to be researched,the basic research and clinical application of GM/IM and CVD will be a hot topic in the future.The research status of the relationship between GM/IM and CVD has been reviewed in present paper for providing diagnosis and treatment ideas and related references for the prevention and treatment of CVD.