早期高压氧急诊抢救对急性脑梗死患者脑血流灌注及神经功能保护效果研究

Study on the Protective Effect of Early Hyperbaric Oxygen Emergency Rescue on Cerebral Blood Perfusion and Neurological Function in Patients with AcuteCerebral Infarction

目的分析对急性脑梗死(ACI)患者给予早期高压氧(HBOT)急诊抢救的临床疗效。方法将2020年2月至2022年3月于本院接受治疗的200例ACI患者以随机抽签法分为两组,每组100例。对照组和观察组分别施以常规治疗和HBOT急诊抢救,两组均连续治疗3周。比较两组治疗前后的脑血流灌注指标(CBV、CBF、MTT、TTP)、神经功能指标(NSE、S100B、GFAP、MBP)、血清SICAM-1、ox-LDL、M-CSF水平以及神经功能缺损情况和生活质量。结果治疗后两组脑血流灌注指标和神经功能指标水平均有所改善,且与对照组相比较,观察组CBV、CBF水平较高,MTT、TTP水平和NSE、S100B、GFAP、MBP水平均较低(P<0.05);治疗后两组血清SICAM-1、ox-LDL、M-CSF水平均有所下降,且与对照组相比较,观察组血清SICAM-1、ox-LDL、M-CSF水平均较低(P<0.05);与对照组相比较,治疗后观察组NIHSS评分较低,ADL评分较高(P<0.05)。结论将早期HBOT治疗应用于ACI患者的急诊抢救,有利于改善患者的脑血流灌注,降低神经功能损伤和血清SICAM-1、ox-LDL、M-CSF水平,改善患者预后。

Objective To analyze the clinical efficacy of early hyperbaric oxygen(HBOT)emergency rescue for patients with acute cerebral infarction(ACI).Methods A total of 200 ACI patients who were treated in our hospital from February 2020 to March 2022 were randomly divided into two groups with 100 cases in each group.The control group and the observation group were given conventional treatment and HBOT emergency rescue respectively,and both groups were treated for 3 consecutive weeks.The cerebral blood perfusion indexes(CBV,CBF,MTT,TTP),neurological function indexes(NSE,S100B,GFAP,MBP),serum SICAM-1,ox-LDL,M-CSF levels and neurological function were compared between the two groups before and after treatment Defect status and quality of life.Results After treatment,the levels of cerebral blood perfusion indexes and neurological function indexes in the two groups were improved.Compared with the control group,the levels of CBV and CBF in the observation group were higher,and the levels of MTT,TTP and NSE,S100B,GFAP,and MBP were higher in the observation group.After treatment,the serum SICAM-1,ox-LDL and M-CSF levels of the two groups were decreased,and compared with the control group,the serum SICAM-1,ox-LDL,M-CSF levels of the observation group CSF levels were lower(P<0.05);after treatment,NIHSS and ADL scores in both groups were improved,and compared with the control group,the NIHSS score in the observation group was lower and the ADL score was higher(P<0.05).Conclusion The application of early HBOT treatment in the emergency rescue of ACI patients is beneficial to improve the cerebral blood perfusion,reduce the neurological damage and serum SICAM-1,ox-LDL and M-CSF levels,and improve the prognosis of the patients.