蓝芩口服液联合干扰素α-2b对疱疹性咽峡炎患儿的疗效及对细胞免疫和炎症因子的影响

Efficacy of Baicalin Oral Solution Combined with Interferon alpha-2b in Children with Herpes Pharyngitis and the Effect on Cellular Immunity and Inflammatory Factors

目的探讨疱疹性咽峡炎患儿联合使用蓝芩口服液、干扰素α-2b的疗效及对细胞免疫和炎症因子的影响。方法选择2019年3月至2023年7月在开封市儿童医院医治的疱疹性咽峡炎患儿进行前瞻性研究,取样82例。使用动态随机盲选法,分成联合组与对照组,各41例。治疗前、治疗7d,评估患儿的细胞免疫【免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、免疫球蛋白A(IgA)】、炎症因子【C反应蛋白(CRP)、白细胞介素-2(IL-2)、降钙素原(PCT)】、康复指标、治疗效果与用药后不良反应。结果组内数值相比,两组患儿治疗7d的IgG、IgM、IgA、IL-2均呈升高趋势,CRP、PCT均呈下降趋势;组间数据相比,联合组治疗7d的IL-2、IgG、IgM、IgA均更高,CRP、PCT更低,差异有统计学意义(P<0.05);与对照组的降温时间、咽峡部疼痛缓解时间、疱疹愈合时间、在院时间相比,联合组更短,差异有统计学意义(P<0.05);在治疗效果上,联合组总有效率(90.24%)比对照组(73.17%)高,差异有统计学意义(P<0.05);在不良反应上,联合组总发生率(7.32%)比对照组(12.19%)低,差异有统计学意义(P<0.05)。结论疱疹性咽峡炎患儿使用蓝芩口服液、干扰素α-2b联合用药方案,疗效显著,可调节患儿细胞免疫状态,抑制炎症因子活性,缩短患儿相关临床症状康复周期,还可降低患儿的药物反应。

Objective To investigate the efficacy of the combination of blue scutellaria oral solution and interferonα-2b in children with herpes pharyngitis and the effects on cellular immunity and inflammatory factors.Methods A sample of 82 children with herpes pharyngitis treated at Kaifeng Children's Hospital from March 2019 to July 2023 were selected for a prospective study.Using a dynamic randomised blinded selection method,41 cases each were divided into a combined group and a control group.Before treatment and at 7 d of treatment,children were assessed for cellular immunity[immunoglobulin G(IgG),immunoglobulin M(IgM),immunoglobulin A(IgA)],inflammatory factors[C-reactive protein(CRP),interleukin-2(IL-2),calcitoninogen(PCT)],recovery indicators,treatment effects and adverse effects after medication.Results Compared with the values within the group,the children in both groups showed an increase in IgG,IgM,IgA and IL-2 and a decrease in CRP and PCT at 7 d of treatment;compared with the data between the groups,the combined group showed higher IL-2,IgG,IgM and IgA and lower CRP and PCT at 7 d of treatment,with statistically significant differences(P<0.05);compared with the control group,the time of hypothermia,the In terms of treatment effect,the total effective rate of the combined group(90.24%)was higher than that of the control group(73.17%),and the difference was statistically significant(P<0.05);in terms of adverse effects,the total incidence of the combined group(7.32%)was lower than that of the control group(12.19%),and the difference was statistically significant(P<0.05);in terms of adverse effects,the total incidence of the combined group(7.32%)was lower than that of the control group(12.19%),and the difference was statistically significant(P<0.05).In terms of adverse reactions,the overall incidence was lower in the combined group(7.32%)than in the control group(12.19%),with a statistically significant difference(P<0.05).Conclusion The combination of Baicalin oral solution and interferonα-2b in children with herpes pharyngitis is effective in regulating the cellular immune status of the children,inhibiting the activity of inflammatory factors,shortening the recovery period of the clinical symptoms and reducing the drug reactions of the children.