罗匹尼罗在原发性不宁腿综合征中治疗的临床应用研究

Clinical Application of Ropinilo in the Treatment of Primary Restless Leg Syndrome

目的分析不宁腿综合征(RLS)应用罗匹尼罗口服治疗后的疗效情况。方法筛选2019年9月至2020年06月在我院就诊的45例原发性不宁腿综合征患者。病情给予分析,同时给予口服罗匹尼罗治疗,分别于术前、治疗一周、术后一月内应用国际不宁腿综合征研究组小组RLS严重程度测定量表(IRLS)评分。比较治疗前、治疗后一周、治疗后一月的效果差异。结果45例确诊患者中其中男16例,女29例;患者年龄分别为43~83岁。平均年龄71.77±8.89岁,高血压和心疾病史的老年患者11例,占24%;糖尿病史的老年患者9例,占20%;吸烟史患者3例,占6.67%;饮酒史患者0例,占0%;治疗前IRLS评分为22.11±3.51分,治疗后一周IRLS评分为11.97±4.74,治疗后一月IRLS评分为4.02±2.38。治疗后一周和治疗前、治愈后一个月的评分之间差异有统计学意义。结论在我院门诊就诊的45位不宁腿综合征患者的研究,予以罗匹尼罗口服治疗,所有患者都得到不同程度的好转,而且总体安全性高。

Objective To explore the effect of oral treatment with ropinib with RLS.Methods A total of 45 patients with primary restless leg syndrome who were visited in our hospital from September 2019 to June 2020 were screened.The patient's condition was analyzed,and oral treatment with ropinib was administered.The International Restless Leg Syndrome Research Group RLS IRLS was used for scoring before surgery,one week of treatment,and one month after surgery.The effect differences before treatment,one week after treatment,and one month after treatment were compared.Results Among the 45 confirmed patients,there were 16 males and 29 females.The patient's age ranged from 43 to 83 years old.There were 11 elderly patients with a history of hypertension and heart disease,accounting for 24%,with an average age of 71.77±8.89 years.9 elderly patients with diabetes history,accounting for 20%.3 patients with a history of smoking,accounting for 6.67%.There was 0 patients with a history of drinking alcohol,accounting for 0%.The IRLS score before treatment was 22.11±3.51 points,one week after treatment was 11.97±4.74 points,and one month after treatment was 4.02±2.38 points.There was a statistically significant difference between the scores one week after treatment,before treatment,and one month after cure.Conclusion A study of 45 patients with restless leg syndrome who were treated with ropinib orally in our outpatient department showed varying degrees of improvement in all patients,and overall safety was high.