摘要
早期诊断并准确评估肝脏炎症和纤维化程度对慢性肝病的治疗干预及预后尤为重要。本文通过回顾高尔基体蛋白73(GP73)与肝癌、肝纤维化及肝脏炎症的诊断、预后方面的研究,归纳总结了目前GP73对于慢性肝病的诊断效能。分析表明除了与肝癌有关外,GP73与肝纤维化程度及预后密切相关,也可较好地反映肝脏炎症损伤。GP73与其他血清标志物联合,可提高慢性肝病的无创诊断效能。
Early diagnosis and accurate assessment of liver inflammation and fibrosis is particularly important for the therapeutic intervention and prognosis of chronic liver diseases.This article summarizes the diagnostic efficacy of Golgi protein 73(GP73)for chronic liver diseases by reviewing related clinical studies on GP73 and the diagnosis and prognosis of liver cancer,liver fibrosis,and liver inflammation.The analysis shows that besides liver cancer,GP73 is closely associated with the degree of liver fibrosis and prognosis and can better reflect liver inflammatory damage.GP73 combined with other serum markers can improve the noninvasive diagnosis of chronic liver diseases.
作者
马杨青
范海纳
孙鑫
刘成海
MA Yangqing;FAN Haina;SUN Xin;LIU Chenghai(Institute of Liver Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shanghai Key Laboratory of Traditional Chinese Clinical Medicine,Shanghai 201203,China;Key Laboratory of Liver and Kidney Diseases,Ministry of Education,Shanghai 201203,China)
出处
《临床肝胆病杂志》
CAS
北大核心
2023年第8期1999-2004,共6页
Journal of Clinical Hepatology
基金
国家自然科学基金(81730109,82274305)
上海市临床重点专科建设项目(shslczdzk01201)
上海市科学技术委员会启明星计划扬帆专项(22YF1449300)
上海中医药大学预算内项目(2021LK081)。
