计算机化认知行为联合阿戈美拉汀治疗精神分裂症后抑郁的临床效果

Clinical Effect of Computerized Cognitive Behavior Therapy Combined With Agomelatin in the Treatment of Post Schizophrenic Depression

目的研究计算机化认知行为(computerized cognitive behavioral therapy,CCBT)联合阿戈美拉汀治疗精神分裂症的临床效果。方法抽取福建省福州神经精神病防治院精神科2020年5月—2022年5月收治的68例精神分裂症后抑郁患者,根据治疗方式不同分为对照组(n=34)与观察组(n=34),对照组患者实行阿戈美拉汀治疗,观察组患者则在此基础上进行CCBT,比较两组患者的临床疗效、抑郁、焦虑评分、日常生活自理能力评分、认知领域评分、生活质量评分、不良反应发生率。结果观察组患者治疗总有效率为97.06%,高于对照组的76.47%(P<0.05)。治疗后,观察组患者抑郁、焦虑评分为(16.74±2.11)、(11.58±5.54)分,低于对照组的(23.73±2.58)、(22.73±5.56)分(P<0.05)。治疗后,观察组患者日常生活自理能力评分为(88.25±4.11)分,高于对照组的(74.21±4.73)分(P<0.05)。观察组患者精神运动速度、社会认知水平、解决问题能力、记忆力、视觉学习测评得分均高于对照组,差异有统计学意义(P<0.05)。观察组患者生理状态、心理状态、精神评分及社会交往评分均高于对照组,差异有统计学意义(P<0.05)。观察组患者不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。结论治疗精神分裂症后抑郁患者,采用CCBT与阿戈美拉汀联合的方式可以切实提升患者的生活质量水平、自理能力,消除患者的负面情绪,达到良好的治疗效果,药物使用安全性与有效性较高,建议临床推广应用。

Objective To study the efficacy of computerized cognitive behavioral therapy(CCBT) combined with agomelatin in the treatment of post schizophrenic depression.Methods A total of 68 patients with post schizophrenia depression admitted to the department of psychiatry at Fuzhou Neuro-Psychiatric Hospital,Fujian Province from May 2020 to May 2022 were selected and divided into control group(n =34) and observation group(n =34)based on different treatment methods.The control group received agomelatin treatment,while the observation group received CCBT on this basis.The clinical efficacy,depression,and anxiety scores of the two groups of patients were compared daily self-care ability score,cognitive domain score,quality of life score,and adverse reaction rate.Results The total effective rate of observation group was 97.06%,which was higher than 76.47% of control group(P<0.05).After treatment,the depression and anxiety scores of the observation group were(16.74±2.11) and(11.58±5.54) points,which were lower than those of the control(23.73±2.58) and(22.73±5.56) points(P<0.05).After treatment,the self-care ability score of the observation group was(88.25±4.11) points,which was higher than that of the control group(74.21±4.73)points(P<0.05).Psychomotor speed,social cognition level,problem solving ability,memory and visual learning test scores in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).The physiological status,psychological status,mental scores and social interaction scores in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).Conclusion In the treatment of post schizophrenic depression patients,the combination of CCBT and argomelatin can effectively improve their quality of life and self care ability,eliminate their negative emotions,and achieve good therapeutic results.Drug use is safe and effective,which is recommended for clinical promotion and application.