摘要
This study aims to detect the expression of heat shock protein gp96(HSPgp96)in osteosarcoma and explore its role in anti-tumor immunity.Expression of HSPgp96 in 45 cases of osteosarcoma,including 24 cases of the osteoblast type,21 cases of chondroblast type and 5 cases of normal bone tissue were detected by immuno-histochemistry(IHC).The expression rate of HSPgp96 was 100%(45/45)in osteosarcoma,compared with 20%(1/5)in normal bone tissue.The average positive cell rates were 97.23%and 0.48%in osteosarcoma and normal bone tissue,respectively,and the difference between them was significant(P<0.01).The positive cell rates in osteoblast type and chondroblast type were 97.78%and 96.56%,respectively,and the difference had no statistical signifi-cance(P>0.05).The expression degree of HSPgp96 in osteosarcoma had a clear correlation with the pathologic degree(P<0.05),while it had no relationship with the clinical stage(P>0.05).The expression of HSPgp96 is high in osteosarcoma and it may be a significant index for judgment of malignancy degree and an important tar-get site of anti-tumor immunity.
基金
supported by the Science and Technology Foundation of HuBei Province of China(Grant No.2006-AA412C50).