Effect of Feixian Recipe on laminin,collagen Ⅰ and Ⅲ in rats with pulmonary fibrosis induced by bleomycin

The aim of this paper is to observe the effect of the Feixian Recipe on pulmonary fibrosis in rats.A rat model with pulmonary fibrosis was established by intra-tracheal injection of bleomycin.On days 14,28 and 45,the contents of laminin,collagen Ⅰ and collagen Ⅲ in lung tissue homogenate in the model group,the sham operated group,the Feixian group and the prednisone group were measured.The contents of laminin and collagen Ⅰ and Ⅲ were decreased significantly by the Feixian Recipe.Feixian Recipe has a significant therapeutic effect on bleo-mycin-induced pulmonary fibrosis in rats.