α-突触核蛋白通过诱发内质网应激促进帕金森病的进展

α-Synuclein Promotes the Progression of Parkinson's Disease by Inducing Endoplasmic Reticulum Stress

帕金森病(Parkinson's disease,PD)是世界上第二常见的神经退行性疾病,发病率呈逐年上升趋势,其病理特征是α-突触核蛋白(α-synuclein,α-Syn)的异常聚集。内质网在维持蛋白质稳态中起重要作用,许多研究表明该细胞器参与了PD及其他神经退行性疾病的进展。病理情况下,包括α-Syn在内的各种未折叠或异常折叠蛋白可能引起内质网应激(endoplasmic reticulum stress,ERS),干扰细胞正常功能,然而α-Syn诱发ERS的分子机制尚未完全明确。本文旨在概述PD进程与病理性α-Syn和ERS的相关性,以及目前的治疗研究进展,为PD的诊断和治疗提供新思路。

Parkinson's disease(PD)is the second most common neurodegenerative disease worldwide,with an increasing incidence over the years.Its pathology is characterized by the abnormal aggregation ofα-synuclein(α-Syn).The endoplasmic reticulum plays a critical role in maintaining protein homeostasis,and numerous studies have shown its involvement in the progression of PD and other neurodegenerative diseases.Under pathological conditions,various unfolded or misfolded proteins,includingα-Syn,may cause endoplasmic reticulum stress(ERS)and interfere with normal cellular function.However,the molecular mechanism of ERS induced byα-Syn has not been fully elucidated.The article aims to summarize the correlation ofα-Syn and ERS with the progression of PD,as well as the current progress in therapeutic research,thus providing new insights for the diagnosis and treatment of PD.