CT冠脉成像联合血清Sortilin、NCAM-1在冠心病诊断中的临床价值分析

Clinical Value of CT Coronary Angiography Combined with Serum Sortilin and NCAM-1 in The Diagnosis of Coronary Heart Disease

目的探究CT冠脉成像联合血清Sortilin、NCAM-1在冠心病(CHD)诊断中的临床价值。方法选取2021年6月-2022年6月我院收治的疑似CHD患者138例为研究对象,经冠状动脉造影诊断为CHD的有96例即为CHD组,其中分急性心肌梗死(AMI组)30例,不稳定型心绞痛(UAP组)34例,稳定型心绞痛(SAP组)32例,同期正常体检健康志愿者88例为对照组。采用酶联免疫吸附测定法(ELISA)测定血清中Sortilin、NCAM-1表达水平;Pearson法分析CHD患者血清中Sortilin和NCAM-1的相关性;绘制受试者工作特征(ROC)曲线分析Sortilin、NCAM-1对CHD的诊断价值;采用四格表评估CT冠脉成像联合血清Sortilin、NCAM-1对CHD的诊断效能。结果与对照组相比,CHD组Sortilin的表达水平显著升高,NCAM-1水平显著降低(P<0.05)。与AMI组相比,UAP组和SAP组患者Sortilin的表达水平显著升高,SAP组显著高于UAP组;UAP组和SAP组患者NCAM-1的表达水平与AMI组相比显著降低,SAP组显著低于UAP组(P<0.05)。相关性分析显示,在CHD患者血清中Sortilin、NCAM-1表达水平呈负相关关系(r=-0.570,P<0.001)。CT冠脉成像联合血清Sortilin、NCAM-1诊断CHD的敏感度较高于CT冠脉成像、Sortilin、NCAM-1单独诊断的敏感度。结论CHD患者血清中Sortilin的表达水平显著升高,NCAM-1水平显著降低,CT冠脉成像联合血清Sortilin、NCAM-1可以提高CHD的诊断效能。

Objective To investigate the clinical value of CT coronary angiography combined with serum Sortilin and NCAM-1 in the diagnosis of coronary heart disease(CHD).Methods A total of 138 suspected CHD patients admitted to our hospital from June 2021 to June 2022 were selected as the study subjects,there were 96 patients diagnosed as CHD by coronary angiography,namely CHD group,including 30 patients with acute myocardial infarction(AMI group),34 patients with unstable angina pectoris(UAP group),and 32 patients with stable angina pectoris(SAP group),in the same period,88 healthy volunteers with normal physical examination were taken as the control group.Enzyme linked immunosorbent assay(ELISA)was applied to determine the expression levels of Sortilin and NCAM-1 in serum;Pearson method was used to analyze the correlation between Sortilin and NCAM-1 in serum of CHD patients;the ROC curve was drawn to analyze the diagnostic value of Sortilin and NCAM-1 for CHD;the diagnostic efficacy of CT coronary angiography combined with serum Sortilin and NCAM-1 in CHD was evaluated with four grid table.Results Compared with the control group,the expression level of Sortilin in CHD group increased obviously,and the level of NCAM-1 decreased obviously(P<0.05).Compared with AMI group,the expression level of Sortilin in UA P group and SAP group was obviously higher than that in UA P group;the expression level of NCAM-1 in UA P group and SAP group was obviously lower than that in AMI group,and that in SAP group was obviously lower than that in UA P group(P<0.05).Correlation analysis showed that the expression levels of Sortilin and NCAM-1 in serum of CHD patients were negatively correlated(r=-0.570,P<0.001).The sensitivity of CT coronary imaging combined with serum Sortilin and NCAM-1 in the diagnosis of CHD was higher than that of CT coronary imaging,Sortilin and NCAM-1 alone.Conclusion The expression level of Sortilin in serum of patients with CHD is obviously increased,and the level of NCAM-1 is obviously decreased.CT coronary angiography combined with serum Sortilin and NCAM-1 can improve the diagnostic efficacy of CHD.