3.0T MRI T2Mapping序列对0~5岁正常儿童髋关节软骨评估的探索性分析

Exploratory Analysis of 3.0T MRI T2Mapping Sequence in The A ssessment of Hip Cartilage in Normal Children Aged 0-5 Years

目的利用3.0T MRI T2Mapping序列对0~5岁正常儿童髋关节软骨行磁共振扫描并量化分析,探究不同阶段髋关节软骨T2值变化规律,初步建立0~5岁正常儿童髋关节软骨T2值的参考范围。方法收集0~5岁发育正常儿童196名,其中男92名,女104名。根据年龄分成5组,分别对所有儿童行髋关节常规序列、T2-mapping序列扫描,在髋臼软骨及与其对应的股骨头软骨划分上、前、后三个区域,共6个亚区,测量其T2值。观察分析组间及组内不同亚区T2值的差异并计算其正常值范围,分析相关因素。结果0~5岁正常儿童髋关节软骨,不同性别各亚区间T2值比较差异均无统计学意义(均P>0.05)。左、右两侧对应亚区T2值比较差异均无统计学意义(均P>0.05)。不同髋关节亚区各年龄组T2值比较,年龄组间T2值差异有统计学意义(均P<0.05)。结论3.0T MRI T2 mapping序列能定量分析儿童髋关节软骨T2值,0~5岁正常儿童髋关节软骨各亚区软骨T2值与年龄相关,与性别和左右无关。

Objective Using 3.0T MRI T2Mapping sequence to conduct MRI scan and quantitative analysis of hip articular cartilage in normal children aged 0-5 years,to explore the changing law of T2 value of hip articular cartilage at different stages under 5 years old and the analysis of related factors,and to preliminarily establish a 0-5 year old child.Reference ranges for T2 values of hip cartilage in normal children.Methods 196 children with normal development were collected,including 92 males and 104 females.They were divided into 5 groups according to their age.Routine hip joint sequence and T2-mapping sequence scans were performed on all children,respectively,and the T2 values were measured in the upper,anterior and posterior regions of the acetabular cartilage and its corresponding femoral head cartilage,totaling 6 subregions.The differences of T2 values between groups and in different sub-regions within the groups were observed and analyzed,and the normal value range was calculated,and the related factors were analyzed.Results There was no significant difference in the T2 value of the hip articular cartilage in normal children aged 0-5 years between different genders and sub-intervals(all P>0.05).There was no significant difference in the T2 values of the corresponding subregions on the left and right sides(both P>0.05).The T2 values of different hip subregions and age groups were compared,and there were significant differences in T2 values between age groups(all P<0.05).Conclusion 3.0T MRI T2 mapping sequence can quantitatively analyze the T2 value of children's hip articular cartilage.The cartilage T2 value of each subregion of hip articular cartilage in normal children aged 0-5 is related to age,but not to gender and left and right.