头发与头皮护理的科学基础(Ⅷ)——防脱生发体外评价方法以及植物防脱原料研究进展

Scientific foundations of hair and scalp care(Ⅷ)Method for in vitro evaluation of hair growth prevention and research progress of plant anti-stripping raw materials

随着科技发展和人们生活水平的改善,大众的审美亦逐渐提高,人们对于外貌尤其是头发方面愈加关注,防脱、生发也成为了大家关注的焦点。脱发,是指头发脱落的一种生理现象,分为生理性脱发和病理性脱发。毛囊(HF)在毛发形态的形成和生长中起着重要作用,不同的细胞信号通路和生长因子参与调控毛囊生长周期。本文基于人真皮乳头细胞(HDPCs)模型,综述了几种体外应激诱导模型,通过模型中标记物的变化,以此来考察和筛选防脱原料的功效。此外,还列举了几种常见的植物防脱原料,并概括其在毛囊中的作用机理,希望为今后防脱生发理论的研究和植物防脱原料开发提供参考。

With the development of science and technology and the improvement of people’s living standards,the public’s aesthetic has gradually improved.People are more and more concerned about the appearance,especially the hair,and the prevention and hair growth have become the focus of everyone’s attention.Alopecia refers to a kind of physiological phenomenon that hair falls off,which is divided into physiological alopecia and pathological alopecia.Hair follicle(HF)plays an important role in the formation and growth of hair morphology,and different cell signaling pathways and growth factors are involved in the regulation of hair follicle growth cycle.Based on the human dermal papilla cell(HDPCs)model,several stress-inducing models in vitro were reviewed in this paper.Through the changes of markers in the models,the efficacy of anti-detachment materials was investigated and screened.In addition,several common plant anti-hair loss materials were listed,and their mechanism of action in hair follicles was summarized,hoping to provide reference for future research on anti-hair loss theory and raw material development.