基于纳米颗粒的内耳给药研究进展

Research Progress on Nanoparticle-Based Inner Ear Drug Delivery

听力损失(Hearing loss,HL)是目前世界上最普遍的感觉障碍之一。药物治疗是主要手段,由于解剖和生理特点限制了大多数药物向内耳组织的有效递送,随着新型纳米材料的不断快速发展,纳米递送系统有望为内耳疾病治疗达到精准治疗。本文通过对内耳的解剖和生理特点、常见内耳给药方式、各种纳米颗粒、纳米颗粒携带的治疗剂、内耳直接给药最佳途径及内耳给药研究中的应用等进行综述,以期为内耳纳米递药提供一定参考。

Hearing loss(HL)is one of the most common sensory disorders in the world.Drug therapy is the main intervention.Due to its unique anatomic and physiological characteristics,effective delivery of most drugs to the inner ear is limited.With the rapid development of new nanomaterials,nano-drug delivery systems are expected to achieve targeted precision treatment for inner ear disorders.In this paper,the anatomical and physiological characteristics of the inner ear,common ways of inner ear drug delivery,various nanoparticles,therapeutic agents carried by nanoparticles,best pathways of direct drug administration into the inner ear and their applications are reviewed,in order to provide a basis for development of inner ear nano-drug delivery.