非小细胞肺癌免疫相关性肺炎研究进展

Progress of Research on Immune-related Pneumonia in Non-small Cell Lung Cancer

近年来,免疫治疗在非小细胞肺癌领域取得突破性进展,重塑了肺癌治疗格局,但是随着免疫治疗在临床的广泛应用,其产生的免疫相关性不良事件越来越受到重视,其中免疫性肺炎作为最受关注的不良反应之一,影响疾病治疗进程和疗效,严重者甚至危及生命。免疫性肺炎发病机制复杂、临床表现多样化,亟需加强对免疫性肺炎的认知能力。免疫性肺炎的治疗手段有限,更多的治疗药物正在探索中。因此,本文对非小细胞肺癌免疫性肺炎的研究进展进行综述。

In recent years,immunotherapy has made a breakthrough in the field of non-small cell lung cancer,reshaping the pattern of lung cancer treatment.However,with the wide application of immunotherapy in clinical practice,immune-related adverse events have attracted increasing attention.Immune pneumonia,as one of the immune-related toxic side effects of greatest concern,affects the treatment process and curative effect and can be a threat to life in serious cases.Given that immune pneumonia has a complicated pathogenesis and diverse clinical manifestations,strengthening the understanding of immune pneumonia is urgently needed.The treatment of immune pneumonia is limited,and additional therapeutic medicines are still awaiting exploration.Therefore,this paper summarizes the progress of the research on immune pneumonia in the treatment of non-small cell lung cancer.