线粒体动力学在白血病中的研究进展

Research Progress of Mitochond rial Dynamics in Leukemia—— Reeview

线粒体是真核细胞最重要的细胞器之一,与细胞的增殖、凋亡、自噬等生命过程密切相关,生物细胞中的线粒体事实上处于高动力学状态,线粒体的融合和分裂及其继发效应在细胞的生命调节中发挥了重要作用。白血病作为一类造血系统恶性疾病,增殖过度、凋亡受限、自噬异常等细胞调节异常是其主要生物学特性,因此,线粒体动力学调控异常在白血病的发病机制及难治、耐药等环节中可能发挥了关键作用。本文就线粒体动力学及其调控异常在白血病发生发展中的作用进行综述,为白血病线粒体动力学调控研究提供理论依据。

Mitochondria is one of the most important organelles of eukaryotic cells,which is closely related to cell proliferation,apoptosis,autophagy and other life processes.Mitochondrias in biological cells are actually in a highly dynamic state.The fusion and division of mitochondria and their secondary effects play an important role in the regulation of cell life.As a malignant disease of hematopoietic system,leukemia is characterized by excessive proliferation,limited apoptosis,abnormal autophagy and other abnormal cell regulation.Therefore,abnormal mitochondrial dynamics regulation may play a key role in the pathogenesis of leukemia,refractory and drug resistance of leukemia.The article reviews the role of mitochondrial dynamics and abnormal regulation in the pathogenesis and development of leukemia,and provides a theoretical basis for the research on the regulation of mitochondrial dynamics in leukemia.