摘要
多发性骨髓瘤(MM)是一种浆细胞恶性增殖性疾病,骨髓间充质干细胞(MSC)在MM的疾病进展过程中发挥着重要作用。与正常供者来源MSC(ND-MSC)相比,MM来源MSC(MM-MSC)表现出基因、信号通路、蛋白质表达水平和自身分泌细胞因子的异常,且其外泌体与骨髓微环境相互影响,以上原因可导致MM细胞增殖、化疗耐药、MM-MSC成骨分化障碍,并影响MM患者的免疫调节能力。为进一步了解MM的发病机理及相关影响因素,本文针对MM-MSC的最新研究进展作一综述。
Multiple myeloma(MM)is a malignant proliferative disease of plasma cells.Bone marrow mesenchymal stem cells(MSC)play an important role in the progression of MM.Compared with normal donor derived MSC(NDMSC),MM patients derived MSC(MM-MSC)exhibit abnormalities in genes,signaling pathways,protein expression levels and cytokines secreted by themselves.Moreover,the exosomes of MM-MSC can interact with the bone marrow microenvironment.The above reasons can lead to MM cell proliferation,chemoresistance,impaired osteogenic differentiation of MM-MSC,and affect the immunomodulatory capacity of MM patients.In order to further understand the pathogenesis and related influencing factors of MM,this paper reviews the latest research progress of MM-MSC.
作者
凌小穗
何海萍
张丽华
李凡
LING Xiao-Sui;HE Hai-Ping;ZHANG Li-Hua;LI Fan(The Affiliated Hospital of Kunming University of Science and Technology;Department of Hematology,the First People′s Hospital of Yunnan Province,Kunming 650032,Yunnan Province,China)
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2023年第4期1233-1236,共4页
Journal of Experimental Hematology
基金
国家自然科学基金(81760028)
云南省临床医学中心开放课题(2019LCZXKF-XY09)
云南省基础研究计划(昆医联合专项)(2018FE001)(-129)
云南省医学学科带头人(D-2018017)。
关键词
多发性骨髓瘤
间充质干细胞
信号通路
细胞因子
骨髓微环境
multiple myeloma
mesenchymal stem cells
signaling pathways
cytokines
bone marrow microenvironment
