骨髓微环境中巨噬细胞调控造血机制的研究进展

Research Progress on the Mechanism of Macrophages Regulating Hematopoiesis in Bone Marrow Microenvironment--Review

骨髓巨噬细胞是造血微环境的重要组成部分,与造血调控和造血干细胞移植(HSCT)关系密切。最近的研究表明,骨髓巨噬细胞是造血干细胞龛的重要组成部分,有助于调控造血干/祖细胞的动员和功能;造血干细胞移植后,骨髓微环境受损,大量巨噬细胞浸润,调控巨噬细胞的相关信号通路能够促进造血的恢复及造血功能重建。体外巨噬细胞与造血干细胞共同培养后,明显增加了造血干细胞数量及克隆形成的能力,证明巨噬细胞在骨髓造血微环境中对造血调控具有重要作用。本文就骨髓造血微环境中巨噬细胞对造血作用的研究进展作一综述。

Bone marrow macrophage is an important component of bone marrow microenvironment,which is closely related to hematopoietic regulation and hematopoietic stem cell transplantation(HSCT).Recent studies have shown that bone marrow macrophage is an important part of hematopoietic stem cell niche,which can help regulate the mobilization and function of hematopoietic stem/progenitor cells.After HSCT,the microenvironment of bone marrow is damaged and a large number of macrophages infiltrate into the bone marrow.Regulating the macrophage-related signal pathways can promote the recovery of hematopoiesis and the reconstruction of hematopoietic function.Co-culture of macrophages and hematopoietic stem cells(HSC)in vitro significantly increased the number of HSCs and their ability of clone formation,which suggests that macrophages play an important role in the regulation of hematopoiesis in the hematopoietic microenvironment of bone marrow.This paper reviews the recent research progress on the role of macrophages in bone marrow hematopoietic microenvironment.